Oxidative stress and schizophrenia: recent breakthroughs from an old story.
Curr Opin Psychiatry
; 27(3): 185-90, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24613987
ABSTRACT
PURPOSE OF REVIEW Oxidative stress has become an exciting area of schizophrenia research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to novel treatment strategies. This review describes how recent methodological advances have allowed the study of oxidative stress to tackle fundamental questions and have provided several conceptual breakthroughs to the field. RECENT FINDINGS:
Recent human studies support the notion that intrinsic susceptibility to oxidative stress may underlie the pathophysiology of schizophrenia. More than one animal model that may be relevant to study the biology of schizophrenia also shows sign of oxidative stress in the brain.SUMMARY:
These advances have made this topic of paramount importance to the understanding of schizophrenia and will play a role in advancing the treatment options. This review covers topics from the classic biochemical studies of human biospecimens to the use of magnetic resonance spectroscopy and novel mouse models, and focuses on highlighting the promising areas of research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Encéfalo
/
Estresse Oxidativo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Psychiatry
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos