Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells.

Rivière, J; Hauer, J; Poirot, L; Brochet, J; Souque, P; Mollier, K; Gouble, A; Charneau, P; Fischer, A; Pâques, F; de Villartay, J-P; Cavazzana, M

Rivière, J; Hauer, J; Poirot, L; Brochet, J; Souque, P; Mollier, K; Gouble, A; Charneau, P; Fischer, A; Pâques, F; de Villartay, J-P; Cavazzana, M.

Afiliação

Rivière J; 1] INSERM U768 Necker Hospital, Paris, France [2] IMAGINE Institute, Paris Descartes University, Paris, France.
Hauer J; 1] INSERM U768 Necker Hospital, Paris, France [2] Department of Pediatric Hematology and Oncology, Children's University Hospital, Düsseldorf, Germany.
Poirot L; Cellectis Therapeutics, Paris, France.
Brochet J; 1] INSERM U768 Necker Hospital, Paris, France [2] IMAGINE Institute, Paris Descartes University, Paris, France.
Souque P; Molecular Virology and Vectorology Laboratory, Pasteur Institute, Paris, France.
Mollier K; Molecular Virology and Vectorology Laboratory, Pasteur Institute, Paris, France.
Gouble A; Cellectis Therapeutics, Paris, France.
Charneau P; Molecular Virology and Vectorology Laboratory, Pasteur Institute, Paris, France.
Fischer A; 1] INSERM U768 Necker Hospital, Paris, France [2] IMAGINE Institute, Paris Descartes University, Paris, France [3] Unit of Pediatric Immuno-Hematology, APHP, Necker Hospital, Paris, France.
Pâques F; Cellectis Therapeutics, Paris, France.
de Villartay JP; 1] INSERM U768 Necker Hospital, Paris, France [2] IMAGINE Institute, Paris Descartes University, Paris, France.
Cavazzana M; 1] INSERM U768 Necker Hospital, Paris, France [2] IMAGINE Institute, Paris Descartes University, Paris, France [3] Department of Biotherapy, APHP, Necker Hospital, Paris, France [4] CIC Biotherapy GHU West, INSERM-APHP, Paris, France.

Gene Ther ; 21(5): 529-32, 2014 May.

Article em En | MEDLINE | ID: mdl-24622732

Assuntos

Endonucleases/genética; Terapia Genética/métodos; Células-Tronco Hematopoéticas/citologia; Recombinação Homóloga/genética; Proteínas Nucleares/genética; Animais; Quebras de DNA de Cadeia Dupla; Reparo do DNA; Desoxirribonucleases de Sítio Específico do Tipo II; Endonucleases/deficiência; Vetores Genéticos; Lentivirus/genética; Camundongos; Camundongos Knockout; Mutação; Proteínas Nucleares/deficiência; Proteínas de Saccharomyces cerevisiae; Transdução Genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Proteínas Nucleares / Terapia Genética / Endonucleases / Recombinação Homóloga Limite: Animals Idioma: En Revista: Gene Ther Assunto da revista: GENETICA MEDICA / TERAPEUTICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: França

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