[Results of combined treatment in locally advanced cancer of the larynx using preoperative thermochemoradiotherapy].
Vopr Onkol
; 59(6): 721-4, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24624780
ABSTRACT
This paper analyzes the results of combined treatment with preoperative thermochemoradiotherapy in 28 patients with locally advanced laryngeal cancer (T3-4N0-3M0). Radiation therapy (RT) 32 Gy was carried out 5 times a week with splitting the daily dose of radiation on the 2 factions (interval 4 hours) on a "1 Gy + 1 Gy," in the days of the local hyperthermia (LGT)--on a "1 Gy + 3 Gy". LGT in an amount of 3-4 sessions was performed two times a week before the 2nd fraction of RT. The course of polychemotherapy was administered concurrently with RT and LGT. In 2-3 weeks after completion of the course thermochemoradiotherapy patients were operated. Organ-saving operations were performed 10 (56%) of 18 patients with primary tumors categories T3 and 2 (20%) of 10 with T4. Postoperative wounds healed by first intention in 21 (75%) patients. The cumulative 5-year overall survival in the whole group (T3-4N0-3) was 89%, for patients without regional metastases (T3-4N0)--100%. Relapse-free survival time for those patients with a primary tumor T3 equaled 94%, T4--90%. Relapse metastases occurred in 20% of patients. Thus, preoperative thermochemoradiotherapy is a highly effective method of treatment for locally advanced cancer of the larynx and does not lead to the development of severe postoperative complications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Neoplasias Laríngeas
/
Terapia Neoadjuvante
/
Tratamentos com Preservação do Órgão
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Hipertermia Induzida
/
Laringectomia
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
Ru
Revista:
Vopr Onkol
Ano de publicação:
2013
Tipo de documento:
Article