Inflammasome: putting the pieces together.
Cell
; 156(6): 1127-1129, 2014 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-24630715
ABSTRACT
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leveduras
/
Príons
/
Transdução de Sinais
/
Proteínas do Citoesqueleto
/
Evolução Biológica
/
Inflamassomos
/
Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2014
Tipo de documento:
Article