Silent mutations make some noise.

Zheng, Siyuan; Kim, Hoon; Verhaak, Roel G W

Zheng, Siyuan; Kim, Hoon; Verhaak, Roel G W.

Afiliação

Zheng S; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kim H; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Verhaak RGW; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: rverhaak@mdanderson.org.

Cell ; 156(6): 1129-1131, 2014 Mar 13.

Article em En | MEDLINE | ID: mdl-24630716

ABSTRACT

ABSTRACT

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

Assuntos

Mutação; Neoplasias/genética; Oncogenes; Sítios de Splice de RNA; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Sítios de Splice de RNA / Mutação / Neoplasias Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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