Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).

Syed, Aleena; Garcia, Marco A; Lyu, Shu-Chen; Bucayu, Robert; Kohli, Arunima; Ishida, Satoru; Berglund, Jelena P; Tsai, Mindy; Maecker, Holden; O'Riordan, Gerri; Galli, Stephen J; Nadeau, Kari C

Syed, Aleena; Garcia, Marco A; Lyu, Shu-Chen; Bucayu, Robert; Kohli, Arunima; Ishida, Satoru; Berglund, Jelena P; Tsai, Mindy; Maecker, Holden; O'Riordan, Gerri; Galli, Stephen J; Nadeau, Kari C.

Afiliação

Syed A; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Garcia MA; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Lyu SC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Bucayu R; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Kohli A; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Ishida S; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Berglund JP; Duke Translational Medicine Institute, Regulatory Affairs, Durham, NC.
Tsai M; Department of Pathology, Stanford University School of Medicine, Stanford, Calif.
Maecker H; Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, Calif.
O'Riordan G; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif.
Galli SJ; Department of Pathology, Stanford University School of Medicine, Stanford, Calif; Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, Calif.
Nadeau KC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address: knadeau@stanford.edu.

J Allergy Clin Immunol ; 133(2): 500-10, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24636474

Assuntos

Dessensibilização Imunológica; Fatores de Transcrição Forkhead/imunologia; Tolerância Imunológica/imunologia; Hipersensibilidade a Amendoim/imunologia; Linfócitos T Reguladores/imunologia; Administração Oral; Adolescente; Adulto; Antígenos/imunologia; Arachis/efeitos adversos; Arachis/imunologia; Criança; Pré-Escolar; Células Dendríticas/imunologia; Método Duplo-Cego; Feminino; Humanos; Imunoglobulina E/sangue; Imunoglobulina G/sangue; Masculino; Metilação; Pessoa de Meia-Idade; Hipersensibilidade a Amendoim/terapia; Adulto Jovem

Palavras-chave

APC; Antigen-induced regulatory T; Antigen-presenting cell; CD40 ligand; CD40L; CFSE; Carboxyfluorescein succinimidyl ester; DBPCFC; DC; Dendritic cell; Double-blind, placebo-controlled food challenge; Effector CD4(+) T; FOXP3; Food allergy; Forkhead box protein 3; IT; Immune tolerant; Induced regulatory T; LAG3; Lymphocyte activation gene 3; MFI; Mean fluorescence intensity; NT; Natural regulatory T; Nonspecific regulatory T; Nontolerant; OFC; OIT; Oral food challenge; Oral immunotherapy; Regulatory T; SPT; Skin prick test; T(R)1; Teff; Treg; Type 1 regulatory T; T regulatory cells; ai-Treg; allergy; desensitization; epigenetics; forkhead box protein 3; iTreg; nTreg; ns-Treg; oral immunotherapy; peanut; tolerance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dessensibilização Imunológica / Linfócitos T Reguladores / Hipersensibilidade a Amendoim / Fatores de Transcrição Forkhead / Tolerância Imunológica Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2014 Tipo de documento: Article

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