Cardiomyocyte specific peroxisome proliferator-activated receptor-&#945; overexpression leads to irreversible damage in ischemic murine heart.

Duerr, Georg D; Heinemann, Jan C; Arnoldi, Vanessa; Feisst, Andreas; Kley, Julian; Ghanem, Alexander; Welz, Armin; Dewald, Oliver

Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart.

Duerr, Georg D; Heinemann, Jan C; Arnoldi, Vanessa; Feisst, Andreas; Kley, Julian; Ghanem, Alexander; Welz, Armin; Dewald, Oliver.

Afiliação

Duerr GD; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Electronic address: daniel.duerr@ukb.uni-bonn.de.
Heinemann JC; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Arnoldi V; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Feisst A; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Kley J; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Ghanem A; Department of Cardiology, Pneomology and Angiology - Medizinische Klinik II, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Welz A; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Dewald O; Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

Life Sci ; 102(2): 88-97, 2014 May 02.

Article em En | MEDLINE | ID: mdl-24657893

Assuntos

Regulação da Expressão Gênica; Isquemia Miocárdica/metabolismo; Isquemia Miocárdica/patologia; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; PPAR alfa/biossíntese; Animais; Morte Celular/genética; Feminino; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Isquemia Miocárdica/genética; PPAR alfa/genética

Palavras-chave

Apoptosis; Chemokines; Diabetes; Inflammation; Ischemia/reperfusion; PPAR-α; Remodeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Isquemia Miocárdica / Miócitos Cardíacos / PPAR alfa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2014 Tipo de documento: Article

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