Multipotent mesenchymal stromal cells in otorhinolaryngology.
Med Hypotheses
; 82(6): 769-73, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24726343
ABSTRACT
Multipotent mesenchymal stromal cells (MSCs) are primitive cells capable of restoring damaged mesenchyme and with the ability to differentiate into mature cells of bone, cartilage, muscle, fat, nerve or fibrous tissues. MSCs are therefore good candidates for applications in regenerative medicine and cell based therapy. They regenerate through self-renewal, differentiational capacity, immune modulation and secretion of bioactive molecules. Authors present a review of MSCs applications in otorhinolaryngology. The major interest is focused on phonosurgery, sensorineural deafness and reconstruction of large tissue defects with bone, cartilage or soft tissue replacement. Current evidence of MSCs treatment efficacy in otorhinolaryngology is based on animal models. The true impact on clinical treatment will not be known until clinical studies prove functional outcomes in human medicine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otolaringologia
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Medicina Regenerativa
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Regeneração Tecidual Guiada
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Células-Tronco Mesenquimais
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Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Med Hypotheses
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
República Tcheca