Prevalence and impact of founder mutations in hereditary breast cancer in Latin America.
Genet Mol Biol
; 37(1 Suppl): 234-40, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24764757
ABSTRACT
Approximately 10% of all cancers are considered hereditary and are primarily caused by germline, high penetrance mutations in cancer predisposition genes. Although most cancer predisposition genes are considered molecularly heterogeneous, displaying hundreds of different disease-causing sequence alterations, founder mutations have been identified in certain populations. In some Latin American countries, founder mutations associated with increased risk of breast and other cancers have been described. This is particularly interesting considering that in most of these countries, populations are highly admixed with genetic contributions from native populations and from the in-flux of several distinct populations of immigrants. In this article, we present a review of the scientific literature on the subject and describe current data available on founder mutations described in the most common breast cancer predisposition genes BRCA1, BRCA2 and TP53.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Genet Mol Biol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil