Superhydrophobic nitric oxide-releasing xerogels.
Acta Biomater
; 10(8): 3442-8, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24797527
ABSTRACT
Superhydrophobic nitric oxide (NO)-releasing xerogels were prepared by spray-coating a fluorinated silane/silica composite onto N-diazeniumdiolate NO donor-modified xerogels. The thickness of the superhydrophobic layer was used to extend NO release durations from 59 to 105h. The resulting xerogels were stable, maintaining superhydrophobicity for up to 1month (the longest duration tested) when immersed in solution, with no leaching of silica or undesirable fragmentation detected. The combination of superhydrophobicity and NO release reduced viable Pseudomonas aeruginosa adhesion by >2-logs. The killing effect of NO was demonstrated at longer bacterial contact times, with superhydrophobic NO-releasing xerogels resulting in 3.8-log reductions in adhered viable bacteria vs. controls. With no observed toxicity to L929 murine fibroblasts, NO-releasing superhydrophobic membranes may be valuable antibacterial coatings for implants as they both reduce adhesion and kill bacteria that do adhere.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Silanos
/
Dióxido de Silício
/
Hidrogéis
/
Nanocápsulas
/
Óxido Nítrico
Idioma:
En
Revista:
Acta Biomater
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos