RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.
Nat Rev Genet
; 15(6): 394-408, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24805120
ABSTRACT
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases - Pol IV and Pol V - and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Polimerases Dirigidas por DNA
/
Metilação de DNA
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Epigênese Genética
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Eucariotos
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Pequeno RNA não Traduzido
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Taiwan