Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium.

Guo, Donglin; Yu, Mengfei; Liu, Qinghua; Cox, Robert H; Liu, Tengxian; Yan, Gan-Xin

Guo, Donglin; Yu, Mengfei; Liu, Qinghua; Cox, Robert H; Liu, Tengxian; Yan, Gan-Xin.

Afiliação

Guo D; Lankenau Institute for Medical Research, Wynnewood, PA; College of Life Science, South-Central University for Nationalities, Wuhan, China. Electronic address: dlguo2013@gmail.com.
Yu M; College of Life Science, South-Central University for Nationalities, Wuhan, China.
Liu Q; College of Life Science, South-Central University for Nationalities, Wuhan, China.
Cox RH; Lankenau Institute for Medical Research, Wynnewood, PA.
Liu T; Lankenau Institute for Medical Research, Wynnewood, PA.
Yan GX; Lankenau Institute for Medical Research, Wynnewood, PA; Jefferson Medical College, Philadelphia, PA.

J Electrocardiol ; 47(5): 642-8, 2014.

Article em En | MEDLINE | ID: mdl-24813353

Assuntos

Potenciais de Ação/fisiologia; Endocárdio/citologia; Hipertrofia Ventricular Esquerda/metabolismo; Hipertrofia Ventricular Esquerda/fisiopatologia; Células Musculares/metabolismo; Canais de Sódio/metabolismo; Animais; Endocárdio/fisiopatologia; Masculino; Técnicas de Patch-Clamp; Coelhos

Palavras-chave

Action potential duration; Late sodium current; Left ventricular hypertrophy; Rate dependence; Transmural dispersion of repolarization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potenciais de Ação / Canais de Sódio / Hipertrofia Ventricular Esquerda / Células Musculares / Endocárdio Limite: Animals Idioma: En Revista: J Electrocardiol Ano de publicação: 2014 Tipo de documento: Article

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