Function and dysfunction of hypocretin/orexin: an energetics point of view.
Annu Rev Neurosci
; 37: 101-16, 2014.
Article
em En
| MEDLINE
| ID: mdl-24821311
The basic elements of animal behavior that are critical to survival include energy, arousal, and motivation: Energy intake and expenditure are fundamental to all organisms for the performance of any type of function; according to the Yerkes-Dodson law, an optimal level of arousal is required for animals to perform normal functions; and motivation is critical to goal-oriented behaviors in higher animals. The brain is the primary organ that controls these elements and, through evolution, has developed specialized structures to accomplish this task. The orexin/hypocretin system in the perifornical/lateral hypothalamus, which was discovered 15 years ago, is one such specialized area. This review summarizes a fast-growing body of evidence discerning how the orexin/hypocretin system integrates internal and external cues to regulate energy intake that can then be used to generate sufficient arousal for animals to perform innate and goal-oriented behaviors.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
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Neuropeptídeos
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Peptídeos e Proteínas de Sinalização Intracelular
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Metabolismo Energético
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Região Hipotalâmica Lateral
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Motivação
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Narcolepsia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Ano de publicação:
2014
Tipo de documento:
Article