Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response.

Ozelo, Margareth C; Vidal, Barbara; Brown, Christine; Notley, Colleen; Hegadorn, Carol; Webster, Sandra; Harpell, Lori; Ahlin, James; Winterborn, Andrew; Handforth, Janine; Arruda, Valder R; Hough, Christine; Lillicrap, David

Ozelo, Margareth C; Vidal, Barbara; Brown, Christine; Notley, Colleen; Hegadorn, Carol; Webster, Sandra; Harpell, Lori; Ahlin, James; Winterborn, Andrew; Handforth, Janine; Arruda, Valder R; Hough, Christine; Lillicrap, David.

Afiliação

Ozelo MC; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada; Instituto Nacional de Tecnologi do Sangue Hemocentro, University of Campinas, Campinas, São Paulo, Brazil; and.
Vidal B; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Brown C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Notley C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Hegadorn C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Webster S; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Harpell L; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Ahlin J; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Winterborn A; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Handforth J; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Arruda VR; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Hough C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;
Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada;

Blood ; 123(26): 4045-53, 2014 Jun 26.

Article em En | MEDLINE | ID: mdl-24829206

Assuntos

Autoanticorpos; Inibidores dos Fatores de Coagulação Sanguínea; Células Endoteliais; Fator VIII; Expressão Gênica; Terapia Genética/métodos; Hemofilia A; Animais; Autoanticorpos/sangue; Autoanticorpos/imunologia; Autoenxertos; Inibidores dos Fatores de Coagulação Sanguínea/sangue; Inibidores dos Fatores de Coagulação Sanguínea/imunologia; Modelos Animais de Doenças; Cães; Células Endoteliais/metabolismo; Células Endoteliais/transplante; Fator VIII/biossíntese; Fator VIII/genética; Fator VIII/imunologia; Vetores Genéticos; Hemofilia A/sangue; Hemofilia A/genética; Hemofilia A/imunologia; Hemofilia A/terapia; Humanos; Lentivirus; Camundongos; Fator 1 de Elongação de Peptídeos/genética; Regiões Promotoras Genéticas; Transdução Genética; Transgenes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Fator VIII / Terapia Genética / Expressão Gênica / Inibidores dos Fatores de Coagulação Sanguínea / Células Endoteliais / Hemofilia A Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Blood Ano de publicação: 2014 Tipo de documento: Article

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