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Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.
Shinohara, Hisaaki; Behar, Marcelo; Inoue, Kentaro; Hiroshima, Michio; Yasuda, Tomoharu; Nagashima, Takeshi; Kimura, Shuhei; Sanjo, Hideki; Maeda, Shiori; Yumoto, Noriko; Ki, Sewon; Akira, Shizuo; Sako, Yasushi; Hoffmann, Alexander; Kurosaki, Tomohiro; Okada-Hatakeyama, Mariko.
Afiliação
  • Shinohara H; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Behar M; Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Institute for Quantitative and Computational Biosciences (QC Bio) and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los An
  • Inoue K; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Hiroshima M; Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center (QBiC), 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan. Cellular Informatics Laboratory, RIKEN, 2-1 Hirosawa, Wako 351-0198, Japan.
  • Yasuda T; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Nagashima T; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Kimura S; Graduate School of Engineering, Tottori University 4-101, Koyama-minami, Tottori 680-8552, Japan.
  • Sanjo H; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Maeda S; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Yumoto N; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Ki S; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Akira S; Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
  • Sako Y; Cellular Informatics Laboratory, RIKEN, 2-1 Hirosawa, Wako 351-0198, Japan.
  • Hoffmann A; Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Institute for Quantitative and Computational Biosciences (QC Bio) and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los An
  • Kurosaki T; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. aho
  • Okada-Hatakeyama M; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. ahoffmann@ucla.edu kurosaki@rcai.riken.jp marikoh@rcai.riken.jp.
Science ; 344(6185): 760-4, 2014 May 16.
Article em En | MEDLINE | ID: mdl-24833394
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos B / NF-kappa B / MAP Quinase Quinase Quinases / Quinase I-kappa B / Proteínas Adaptadoras de Sinalização CARD / Guanilato Ciclase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Science Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos B / NF-kappa B / MAP Quinase Quinase Quinases / Quinase I-kappa B / Proteínas Adaptadoras de Sinalização CARD / Guanilato Ciclase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Science Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Japão