Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with ß-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.
Clin Infect Dis
; 59(6): 862-5, 2014 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-24879786
ABSTRACT
Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with ß-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
/
Streptococcus pneumoniae
/
Linfócitos B
/
Talassemia beta
/
Epitopos de Linfócito B
/
Vacinas Pneumocócicas
Tipo de estudo:
Guideline
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2014
Tipo de documento:
Article