Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.
Sex Transm Dis
; 41(7): 440-6, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24922103
ABSTRACT
BACKGROUND:
Single-nucleotide polymorphisms (SNPs) in toll-like receptors (TLR) 1, 2, and 6 impair cell signaling in response to spirochetal lipoproteins. We investigated whether common SNPs in TLR1, TLR2, or TLR6 were associated with laboratory- or clinically-defined neurosyphilis.METHODS:
Polymorphisms in the genes for TLR1 (a TâG mutation at position 1805), TLR2 (a GâA mutation at position 2258), and TLR6 (a CâT mutation at position 745) were sought in 456 white patients with syphilis. Laboratory-defined neurosyphilis included a reactive cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory (VDRL) test. Clinically-defined neurosyphilis included new vision or hearing loss. Controls had CSF white blood cells of 5/µL or less, nonreactive CSF-Venereal Disease Research Laboratory, and no vision or hearing loss.RESULTS:
Overall, 26.2% of patients had laboratory-defined and 36.2% had clinically-defined neurosyphilis. Compared with controls, patients with any of the 3 SNPs were more likely to have laboratory-defined neurosyphilis. Those with TLR2 or TLR6 SNPs were more likely to have clinically-defined neurosyphilis. These associations were independent of serum rapid plasma reagin titer.CONCLUSIONS:
A common TLR1 polymorphism is associated with an increased risk of laboratory-defined neurosyphilis, and common TLR2 and TLR6 polymorphisms are associated with an increased risk of both laboratory- and clinically-defined neurosyphilis. These data suggest that host factors impact the natural history of syphilis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Punção Espinal
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Treponema pallidum
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Polimorfismo de Nucleotídeo Único
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Receptor 1 Toll-Like
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Receptor 2 Toll-Like
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Receptor 6 Toll-Like
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Neurossífilis
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Sex Transm Dis
Ano de publicação:
2014
Tipo de documento:
Article