The Construction of All-Carbon Quaternary Stereocenters by Use of Pd-Catalyzed Asymmetric Allylic Alkylation Reactions in Total Synthesis.
European J Org Chem
; 2013(14): 2745-2759, 2013 May 01.
Article
em En
| MEDLINE
| ID: mdl-24944521
ABSTRACT
All-carbon quaternary stereocenters have posed significant challenges in the synthesis of complex natural products. These important structural motifs have inspired the development of broadly applicable palladium-catalyzed asymmetric allylic alkylation reactions of unstabilized non-biased enolates for the synthesis of enantioenriched α-quaternary products. This microreview outlines key considerations in the application of palladium-catalyzed asymmetric allylic alkylation reactions and presents recent total syntheses of complex natural products that have employed these powerful transformations for the direct, catalytic, enantioselective construction of all-carbon quaternary stereocenters.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
European J Org Chem
Ano de publicação:
2013
Tipo de documento:
Article