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The histone variant H2A.W defines heterochromatin and promotes chromatin condensation in Arabidopsis.
Yelagandula, Ramesh; Stroud, Hume; Holec, Sarah; Zhou, Keda; Feng, Suhua; Zhong, Xuehua; Muthurajan, Uma M; Nie, Xin; Kawashima, Tomokazu; Groth, Martin; Luger, Karolin; Jacobsen, Steven E; Berger, Frédéric.
Afiliação
  • Yelagandula R; Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore.
  • Stroud H; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Holec S; Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore.
  • Zhou K; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
  • Feng S; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute
  • Zhong X; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Muthurajan UM; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA.
  • Nie X; Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore.
  • Kawashima T; Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore.
  • Groth M; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Luger K; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA; Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO 80523, USA.
  • Jacobsen SE; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute
  • Berger F; Temasek Lifesciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore, Singapore. Electronic address: fred@tll.org.sg.
Cell ; 158(1): 98-109, 2014 Jul 03.
Article em En | MEDLINE | ID: mdl-24995981
ABSTRACT
Histone variants play crucial roles in gene expression, genome integrity, and chromosome segregation. We report that the four H2A variants in Arabidopsis define different genomic features, contributing to overall genomic organization. The histone variant H2A.W marks heterochromatin specifically and acts in synergy with heterochromatic marks H3K9me2 and DNA methylation to maintain transposon silencing. In vitro, H2A.W enhances chromatin condensation by promoting fiber-to-fiber interactions via its conserved C-terminal motif. In vivo, H2A.W is required for heterochromatin condensation, demonstrating that H2A.W plays critical roles in heterochromatin organization. Similarities in conserved motifs between H2A.W and another H2A variant in metazoans suggest that plants and animals share common mechanisms for heterochromatin condensation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Heterocromatina / Histonas / Arabidopsis / Proteínas de Arabidopsis / Montagem e Desmontagem da Cromatina Idioma: En Revista: Cell Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Heterocromatina / Histonas / Arabidopsis / Proteínas de Arabidopsis / Montagem e Desmontagem da Cromatina Idioma: En Revista: Cell Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Singapura