Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation.

Cristóbal, Ion; Rincón, Raúl; Manso, Rebeca; Madoz-Gúrpide, Juan; Caramés, Cristina; del Puerto-Nevado, Laura; Rojo, Federico; García-Foncillas, Jesús

Cristóbal, Ion; Rincón, Raúl; Manso, Rebeca; Madoz-Gúrpide, Juan; Caramés, Cristina; del Puerto-Nevado, Laura; Rojo, Federico; García-Foncillas, Jesús.

Afiliação

Cristóbal I; Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain. Electronic address: ion.cristobal@fjd.es.
Rincón R; Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
Manso R; Pathology Department, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
Madoz-Gúrpide J; Pathology Department, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
Caramés C; Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
del Puerto-Nevado L; Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
Rojo F; Pathology Department, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain.
García-Foncillas J; Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Autonomous University of Madrid, E-28040 Madrid, Spain. Electronic address: jgfoncillas@gmail.com.

Biochim Biophys Acta ; 1842(9): 1823-9, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24997451

Assuntos

Proliferação de Células/efeitos dos fármacos; Colforsina/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Proteína Fosfatase 2/metabolismo; Vasodilatadores/farmacologia; Idoso; Idoso de 80 Anos ou mais; Antimetabólitos Antineoplásicos/farmacologia; Antineoplásicos/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica; Apoptose/efeitos dos fármacos; Western Blotting; Neoplasias Colorretais/patologia; Inibidores Enzimáticos/farmacologia; Feminino; Fluoruracila/farmacologia; Humanos; Técnicas Imunoenzimáticas; Masculino; Pessoa de Meia-Idade; Ácido Okadáico/farmacologia; Compostos Organoplatínicos/farmacologia; Oxaliplatina; Fosforilação/efeitos dos fármacos; Células Tumorais Cultivadas

Palavras-chave

5-Fluorouracil; Colorectal cancer; Forskolin; Oxaliplatin; PP2A-C phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasodilatadores / Colforsina / Neoplasias Colorretais / Proliferação de Células / Proteína Fosfatase 2 Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2014 Tipo de documento: Article

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