Cutaneous adverse reactions to lenalidomide.

Imbesi, S; Allegra, A; Calapai, G; Musolino, C; Gangemi, S

Imbesi, S; Allegra, A; Calapai, G; Musolino, C; Gangemi, S.

Afiliação

Imbesi S; Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Italy. Electronic address: sele19pf@gmail.com.
Allegra A; Division of Hematology, University of Messina, Italy.
Calapai G; Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy.
Musolino C; Division of Hematology, University of Messina, Italy.
Gangemi S; Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Italy; Institute of Biomedicine and Molecular Immunology "A. Monroy" (IBIM) - Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy.

Allergol Immunopathol (Madr) ; 43(1): 88-91, 2015.

Article em En | MEDLINE | ID: mdl-24998775

ABSTRACT

ABSTRACT

Lenalidomide is an immunomodulatory drug (IMiD) used principally in the treatment of multiple myeloma (MM), myelodysplastic syndromes (MS) and amyloidosis. Adverse reactions related to lenalidomide include myelosuppression (mainly neutropenia but also thrombocytopenia), gastrointestinal problems, skin eruption, atrial fibrillation and asthenia, decreased peripheral blood stem cell yield during stem cell collection, venous thromboembolism, and secondary malignances. In this review we focused our attention on the cutaneous adverse reactions to lenalidomide.

Assuntos

Amiloidose/tratamento farmacológico; Toxidermias/prevenção & controle; Mieloma Múltiplo/tratamento farmacológico; Síndromes Mielodisplásicas/tratamento farmacológico; Pele/efeitos dos fármacos; Talidomida/análogos & derivados; Amiloidose/complicações; Animais; Toxidermias/etiologia; Humanos; Lenalidomida; Mieloma Múltiplo/complicações; Síndromes Mielodisplásicas/complicações; Pele/patologia; Talidomida/efeitos adversos; Talidomida/uso terapêutico

Palavras-chave

Adverse cutaneous reactions; Amyloidosis; Erythema multiforme; Immunomodulatory drugs; Lenalidomide; Multiple myeloma; Myelodisplastic syndromes; StevensJohnson syndrome; Toxic epidermal necrolysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Talidomida / Síndromes Mielodisplásicas / Toxidermias / Amiloidose / Mieloma Múltiplo Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2015 Tipo de documento: Article

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