Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort.
Dev Psychopathol
; 27(1): 309-18, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25003328
ABSTRACT
Polymorphisms in the oxytocin receptor gene are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N = 404), collecting youth, mother, and clinician reports of conduct-disordered and antisocial behavior at ages 15 and 20. The oxytocin receptor gene rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling results revealed a significant main effect at age 15 (p = .025); those with the G allele exhibited higher levels of conduct problems. Structural equation modeling revealed a significant Gene × Environment interaction at age 20 (p = .029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared, and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Comportamento Social
/
Estresse Psicológico
/
Comportamento do Adolescente
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Receptores de Ocitocina
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Transtorno da Conduta
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Interação Gene-Ambiente
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Dev Psychopathol
Assunto da revista:
PSICOLOGIA
/
PSIQUIATRIA
Ano de publicação:
2015
Tipo de documento:
Article