Mutant ß-III spectrin causes mGluR1&#945; mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.

Armbrust, Karen R; Wang, Xinming; Hathorn, Tyisha J; Cramer, Samuel W; Chen, Gang; Zu, Tao; Kangas, Takashi; Zink, Anastasia N; Öz, Gülin; Ebner, Timothy J; Ranum, Laura P W

Mutant ß-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.

Armbrust, Karen R; Wang, Xinming; Hathorn, Tyisha J; Cramer, Samuel W; Chen, Gang; Zu, Tao; Kangas, Takashi; Zink, Anastasia N; Öz, Gülin; Ebner, Timothy J; Ranum, Laura P W.

Afiliação

Armbrust KR; Departments of Genetics, Cell Biology and Development.
Wang X; Neuroscience, and.
Hathorn TJ; Center for NeuroGenetics, Department of Molecular Genetics and Microbiology, Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610.
Cramer SW; Neuroscience, and.
Chen G; Neuroscience, and.
Zu T; Center for NeuroGenetics, Department of Molecular Genetics and Microbiology, Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610.
Kangas T; Departments of Genetics, Cell Biology and Development.
Zink AN; Departments of Genetics, Cell Biology and Development.
Öz G; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455 and.
Ebner TJ; Neuroscience, and.
Ranum LP; Departments of Genetics, Cell Biology and Development, Center for NeuroGenetics, Department of Molecular Genetics and Microbiology, Department of Neurology, and Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610 ranum@ufl.edu.

J Neurosci ; 34(30): 9891-904, 2014 Jul 23.

Article em En | MEDLINE | ID: mdl-25057192

Assuntos

Modelos Animais de Doenças; Mutação/genética; Receptores de Glutamato Metabotrópico/análise; Receptores de Glutamato Metabotrópico/genética; Espectrina/genética; Ataxias Espinocerebelares/genética; Animais; Cerebelo/química; Cerebelo/patologia; Espinhas Dendríticas/química; Espinhas Dendríticas/patologia; Feminino; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Receptores de Glutamato Metabotrópico/metabolismo; Ataxias Espinocerebelares/fisiopatologia

Palavras-chave

Purkinje cells; long term potentiation; mGluR1α; mouse model; neurodegeneration; spinocerebellar ataxia type 5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrina / Receptores de Glutamato Metabotrópico / Ataxias Espinocerebelares / Modelos Animais de Doenças / Mutação Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Ano de publicação: 2014 Tipo de documento: Article

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