Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

Lozovaya, N; Gataullina, S; Tsintsadze, T; Tsintsadze, V; Pallesi-Pocachard, E; Minlebaev, M; Goriounova, N A; Buhler, E; Watrin, F; Shityakov, S; Becker, A J; Bordey, A; Milh, M; Scavarda, D; Bulteau, C; Dorfmuller, G; Delalande, O; Represa, A; Cardoso, C; Dulac, O; Ben-Ari, Y; Burnashev, N

Lozovaya, N; Gataullina, S; Tsintsadze, T; Tsintsadze, V; Pallesi-Pocachard, E; Minlebaev, M; Goriounova, N A; Buhler, E; Watrin, F; Shityakov, S; Becker, A J; Bordey, A; Milh, M; Scavarda, D; Bulteau, C; Dorfmuller, G; Delalande, O; Represa, A; Cardoso, C; Dulac, O; Ben-Ari, Y; Burnashev, N.

Afiliação

Lozovaya N; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France [3] INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette, 149 Rue de Sèv
Gataullina S; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France [3] INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette, 149 Rue de Sèv
Tsintsadze T; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France [3].
Tsintsadze V; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Pallesi-Pocachard E; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Minlebaev M; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France [3] Laboratory of Neurobiology, Kazan Federal University, Kremlevskaya street 18,
Goriounova NA; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Buhler E; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Watrin F; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Shityakov S; Department of Anaesthesia and Critical Care, University of Würzburg, Josef-Schneider-Street 2, 97080 Würzburg, Germany.
Becker AJ; Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Street 25, D-53105 Bonn, Germany.
Bordey A; Neurosurgery, and Cellular and Molecular Physiology Departments, Yale University School of Medicine, PO Box 208082, New Haven, Connecticut 06520-8082, USA.
Milh M; APHM, Department of Pediatric Neurosurgery and Neurology, CHU Timone, 264 Rue Saint-Pierre, 13385 Marseille Cedex 5, France.
Scavarda D; APHM, Department of Pediatric Neurosurgery and Neurology, CHU Timone, 264 Rue Saint-Pierre, 13385 Marseille Cedex 5, France.
Bulteau C; 1] INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette, 149 Rue de Sèvres, 75015 Paris, France [2] Department of Pediatric Neurosurgery, Foundation Rothschild, 29 Rue Manin, 75019 Paris, France.
Dorfmuller G; 1] INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette, 149 Rue de Sèvres, 75015 Paris, France [2] Department of Pediatric Neurosurgery, Foundation Rothschild, 29 Rue Manin, 75019 Paris, France.
Delalande O; Department of Pediatric Neurosurgery, Foundation Rothschild, 29 Rue Manin, 75019 Paris, France.
Represa A; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Cardoso C; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Dulac O; 1] INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette, 149 Rue de Sèvres, 75015 Paris, France [2] Department of Pediatric Neurosurgery, Foundation Rothschild, 29 Rue Manin, 75019 Paris, France [3] APHP, Necker Hospital, 149 Rue de Sèvres, 75015 Paris, France.
Ben-Ari Y; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.
Burnashev N; 1] INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163, route de Luminy-BP 13, 13273 Marseille Cedex 09, France [2] UMR901, Aix-Marseille University, 58 Boulevard Charles Livon, 13284 Marseille, France.

Nat Commun ; 5: 4563, 2014 Aug 01.

Article em En | MEDLINE | ID: mdl-25081057

Assuntos

Anticonvulsivantes/farmacologia; Epilepsia/tratamento farmacológico; Pirazóis/farmacologia; Quinolonas/farmacologia; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Serina-Treonina Quinases TOR/genética; Esclerose Tuberosa/tratamento farmacológico; Proteínas Supressoras de Tumor/genética; Potenciais de Ação/efeitos dos fármacos; Animais; Modelos Animais de Doenças; Eletroencefalografia; Epilepsia/genética; Epilepsia/metabolismo; Epilepsia/patologia; Regulação da Expressão Gênica; Heterozigoto; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Microtomia; Neocórtex/efeitos dos fármacos; Neocórtex/metabolismo; Neocórtex/patologia; Técnicas de Patch-Clamp; Receptores de N-Metil-D-Aspartato/genética; Receptores de N-Metil-D-Aspartato/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Técnicas de Cultura de Tecidos; Esclerose Tuberosa/genética; Esclerose Tuberosa/metabolismo; Esclerose Tuberosa/patologia; Proteína 1 do Complexo Esclerose Tuberosa; Proteínas Supressoras de Tumor/deficiência

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Esclerose Tuberosa / Receptores de N-Metil-D-Aspartato / Quinolonas / Proteínas Supressoras de Tumor / Epilepsia / Serina-Treonina Quinases TOR / Anticonvulsivantes Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article

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