Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.

Cheng, Ming-Fu; Ou, Li-Chin; Chen, Shu-Chun; Chang, Wan-Ting; Law, Ping-Yee; Loh, Horace H; Chao, Yu-Sheng; Shih, Chuan; Yeh, Shiu-Hwa; Ueng, Shau-Hua

Cheng, Ming-Fu; Ou, Li-Chin; Chen, Shu-Chun; Chang, Wan-Ting; Law, Ping-Yee; Loh, Horace H; Chao, Yu-Sheng; Shih, Chuan; Yeh, Shiu-Hwa; Ueng, Shau-Hua.

Afiliação

Cheng MF; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Ou LC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Chen SC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Chang WT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Law PY; Department of Pharmacology, University of Minnesota, Medical School, Minneapolis, MN 55455, USA.
Loh HH; Department of Pharmacology, University of Minnesota, Medical School, Minneapolis, MN 55455, USA.
Chao YS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Shih C; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC.
Yeh SH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC. Electronic address: bau9763@bp.nhri.org.tw.
Ueng SH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, ROC. Electronic address: shueng@nhri.org.tw.

Bioorg Med Chem ; 22(17): 4694-703, 2014 Sep 01.

Article em En | MEDLINE | ID: mdl-25087049

Assuntos

Analgésicos/farmacologia; Descoberta de Drogas; Indazóis/farmacologia; Receptores Opioides kappa/agonistas; Receptores Opioides mu/agonistas; Analgésicos/uso terapêutico; Animais; Relação Dose-Resposta a Droga; Células HEK293; Humanos; Indazóis/síntese química; Indazóis/química; Camundongos; Camundongos Congênicos; Estrutura Molecular; Dor/tratamento farmacológico; Medição da Dor; Relação Estrutura-Atividade; Cauda/efeitos dos fármacos

Palavras-chave

Anti-nociceptive effects; Structureactivity relationship; Tail-flick test; µ/κ opioid receptor agonist

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides kappa / Receptores Opioides mu / Descoberta de Drogas / Analgésicos / Indazóis Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article

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