Physiologically based pharmacokinetic prediction of telmisartan in human.

Li, Rui; Ghosh, Avijit; Maurer, Tristan S; Kimoto, Emi; Barton, Hugh A

Li, Rui; Ghosh, Avijit; Maurer, Tristan S; Kimoto, Emi; Barton, Hugh A.

Afiliação

Li R; Department of Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Cambridge, MA (R.L., A.G., T.S.M.) and Groton, CT (E.K., H.A.B.).
Ghosh A; Department of Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Cambridge, MA (R.L., A.G., T.S.M.) and Groton, CT (E.K., H.A.B.).
Maurer TS; Department of Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Cambridge, MA (R.L., A.G., T.S.M.) and Groton, CT (E.K., H.A.B.).
Kimoto E; Department of Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Cambridge, MA (R.L., A.G., T.S.M.) and Groton, CT (E.K., H.A.B.).
Barton HA; Department of Pharmacokinetics, Dynamics, and Metabolism, Worldwide Research and Development, Pfizer Inc., Cambridge, MA (R.L., A.G., T.S.M.) and Groton, CT (E.K., H.A.B.) Hugh.Barton@pfizer.com.

Drug Metab Dispos ; 42(10): 1646-55, 2014 Oct.

Article em En | MEDLINE | ID: mdl-25092714

Assuntos

Benzimidazóis/farmacocinética; Benzoatos/farmacocinética; Hepatócitos/metabolismo; Microssomos Hepáticos/metabolismo; Simulação por Computador; Humanos; Modelos Biológicos; Transportadores de Ânions Orgânicos/metabolismo; Telmisartan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Benzoatos / Microssomos Hepáticos / Hepatócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article

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