Ciprofloxacin in combination with other antimicrobials.

Combinations of ciprofloxacin with aminoglycosides or beta-lactams are infrequently synergistic and only rarely antagonistic against Enterobacteriaceae or gram-positive bacteria. Against Pseudomonas aeruginosa, combinations of ciprofloxacin with an aminoglycoside are synergistic for a minority of isolates, whereas rates of synergistic interactions between ciprofloxacin and beta-lactams against this group of organisms vary over a wide range.