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Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NFκB-mediated induction of MMP2.
Bilandzic, Maree; Wang, Yao; Ahmed, Nuzhat; Luwor, Rodney B; Zhu, Hong Jian; Findlay, Jock K; Stenvers, Kaye L.
Afiliação
  • Bilandzic M; MIMR-PHI Institute of Medical Research, Clayton, Vic. 3168, Australia. Electronic address: maree.bilandzic@mimr-phi.org.
  • Wang Y; MIMR-PHI Institute of Medical Research, Clayton, Vic. 3168, Australia.
  • Ahmed N; MIMR-PHI Institute of Medical Research, Clayton, Vic. 3168, Australia; Women's Cancer Research Centre, Royal Women's Hospital, Parkville, Vic. 3052, Australia; Department of Obstetrics and Gynaecology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic. 3052, Australia.
  • Luwor RB; Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic. 3052, Australia.
  • Zhu HJ; Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic. 3052, Australia.
  • Findlay JK; MIMR-PHI Institute of Medical Research, Clayton, Vic. 3168, Australia; Women's Cancer Research Centre, Royal Women's Hospital, Parkville, Vic. 3052, Australia; Department of Obstetrics and Gynaecology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Vic. 3052, Australia.
  • Stenvers KL; MIMR-PHI Institute of Medical Research, Clayton, Vic. 3168, Australia; Department of Developmental Biology and Anatomy, Monash University, Clayton, Vic. 3168, Australia.
Cancer Lett ; 354(1): 107-14, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25128652
ABSTRACT
Metastatic ovarian granulosa cell tumors (GCT) exhibit loss of betaglycan. Here we test the hypothesis that betaglycan blocks GCT metastasis by suppressing NFκB/TGFß2-induced matrix metalloprotinease-2 (MMP2). Human GCT and a human GCT cell model demonstrated prominent MMP2 expression, which was dependent on NFκB activity and stimulated by TGFß2 in an NFκB-dependent manner. Betaglycan suppressed both basal and TGFß2-induced MMP2 expression and countered metastatic behaviors of GCT cells in non-adherent spheroid culture and in vivo xenograft models of metastasis. These data suggest that NFκB/TGFß2 promotes, and betaglycan impedes, the early stages of GCT metastasis, when tumor cells first invade the peritoneum.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Proteoglicanas / NF-kappa B / Receptores de Fatores de Crescimento Transformadores beta / Metaloproteinase 2 da Matriz / Tumor de Células da Granulosa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Proteoglicanas / NF-kappa B / Receptores de Fatores de Crescimento Transformadores beta / Metaloproteinase 2 da Matriz / Tumor de Células da Granulosa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2014 Tipo de documento: Article