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Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Hysi, Pirro G; Cheng, Ching-Yu; Springelkamp, Henriët; Macgregor, Stuart; Bailey, Jessica N Cooke; Wojciechowski, Robert; Vitart, Veronique; Nag, Abhishek; Hewitt, Alex W; Höhn, René; Venturini, Cristina; Mirshahi, Alireza; Ramdas, Wishal D; Thorleifsson, Gudmar; Vithana, Eranga; Khor, Chiea-Chuen; Stefansson, Arni B; Liao, Jiemin; Haines, Jonathan L; Amin, Najaf; Wang, Ya Xing; Wild, Philipp S; Ozel, Ayse B; Li, Jun Z; Fleck, Brian W; Zeller, Tanja; Staffieri, Sandra E; Teo, Yik-Ying; Cuellar-Partida, Gabriel; Luo, Xiaoyan; Allingham, R Rand; Richards, Julia E; Senft, Andrea; Karssen, Lennart C; Zheng, Yingfeng; Bellenguez, Céline; Xu, Liang; Iglesias, Adriana I; Wilson, James F; Kang, Jae H; van Leeuwen, Elisabeth M; Jonsson, Vesteinn; Thorsteinsdottir, Unnur; Despriet, Dominiek D G; Ennis, Sarah; Moroi, Sayoko E; Martin, Nicholas G; Jansonius, Nomdo M; Yazar, Seyhan; Tai, E-Shyong.
Afiliação
  • Hysi PG; Department of Twin Research and Genetic Epidemiology, King's College London, UK.
  • Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Springelkamp H; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.
  • Macgregor S; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Bailey JNC; Duke-National University of Singapore, Graduate Medical School, Singapore.
  • Wojciechowski R; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Vitart V; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Nag A; Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.
  • Hewitt AW; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
  • Höhn R; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD, USA.
  • Venturini C; National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.
  • Mirshahi A; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh.
  • Ramdas WD; Department of Twin Research and Genetic Epidemiology, King's College London, UK.
  • Thorleifsson G; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.
  • Vithana E; Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
  • Khor CC; Department of Twin Research and Genetic Epidemiology, King's College London, UK.
  • Stefansson AB; Institute of Ophthalmology, University College London, UK.
  • Liao J; Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
  • Haines JL; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Wang YX; deCODE/Amgen, 101 Reykjavik, Iceland.
  • Wild PS; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Ozel AB; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.
  • Li JZ; Duke-National University of Singapore, Graduate Medical School, Singapore.
  • Fleck BW; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.
  • Zeller T; Division of Human Genetics, Genome Institute of Singapore, Singapore.
  • Staffieri SE; Eye Clinic, 105 Reykjavik, Iceland.
  • Teo YY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Cuellar-Partida G; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.
  • Luo X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
  • Allingham RR; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Richards JE; Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.
  • Senft A; Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany.
  • Karssen LC; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Zheng Y; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Bellenguez C; NHS Princess Alexandra Eye Pavilion, Edinburgh, UK.
  • Xu L; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany.
  • Iglesias AI; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.
  • Wilson JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Kang JH; Department of Statistics and Applied Probability, National University of Singapore, Singapore.
  • van Leeuwen EM; Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.
  • Jonsson V; Duke University, Duke Eye Center, Durham, NC, USA.
  • Thorsteinsdottir U; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
  • Despriet DDG; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Ennis S; Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.
  • Moroi SE; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Martin NG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Jansonius NM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Yazar S; Inserm, UMR774, Lille, France.
  • Tai ES; Université Lille 2, Lille, France.
Nat Genet ; 46(10): 1126-1130, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25173106
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glaucoma / Predisposição Genética para Doença / Estudo de Associação Genômica Ampla / Loci Gênicos / Pressão Intraocular Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glaucoma / Predisposição Genética para Doença / Estudo de Associação Genômica Ampla / Loci Gênicos / Pressão Intraocular Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article