Extrahepatic platelet-derived growth factor-ß, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice.

Yoshida, Shuhei; Ikenaga, Naoki; Liu, Susan B; Peng, Zhen-Wei; Chung, Jeanhee; Sverdlov, Deanna Y; Miyamoto, Makoto; Kim, Yong Ook; Ogawa, Shinji; Arch, Robert H; Schuppan, Detlef; Popov, Yury

Yoshida, Shuhei; Ikenaga, Naoki; Liu, Susan B; Peng, Zhen-Wei; Chung, Jeanhee; Sverdlov, Deanna Y; Miyamoto, Makoto; Kim, Yong Ook; Ogawa, Shinji; Arch, Robert H; Schuppan, Detlef; Popov, Yury.

Afiliação

Yoshida S; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Ikenaga N; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Liu SB; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Peng ZW; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Chung J; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Sverdlov DY; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Miyamoto M; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Kim YO; Institute of Translational Immunology, University Medical Center, Mainz, Germany.
Ogawa S; Pfizer, Inc, Cambridge, Massachusetts.
Arch RH; Pfizer, Inc, Cambridge, Massachusetts.
Schuppan D; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Institute of Translational Immunology, University Medical Center, Mainz, Germany.
Popov Y; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address: ypopov@bidmc.harvard.edu.

Gastroenterology ; 147(6): 1378-92, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25173753

Assuntos

Ductos Biliares Extra-Hepáticos/metabolismo; Plaquetas/metabolismo; Células Estreladas do Fígado/metabolismo; Cirrose Hepática/metabolismo; Proteínas Proto-Oncogênicas c-sis/metabolismo; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Anticorpos Monoclonais/farmacologia; Anticorpos Neutralizantes/farmacologia; Aspirina/farmacologia; Plaquetas/efeitos dos fármacos; Plaquetas/imunologia; Modelos Animais de Doenças; Feminino; Humanos; Cirrose Hepática/tratamento farmacológico; Cirrose Hepática/patologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pessoa de Meia-Idade; Inibidores da Agregação Plaquetária/farmacologia; Proteínas Proto-Oncogênicas c-sis/genética; Proteínas Proto-Oncogênicas c-sis/imunologia; RNA Mensageiro/metabolismo; Membro 4 da Subfamília B de Transportadores de Cassetes de Ligação de ATP

Palavras-chave

Chronic Liver Injury; Mouse Model; PBC; PSC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Ductos Biliares Extra-Hepáticos / Proteínas Proto-Oncogênicas c-sis / Células Estreladas do Fígado / Cirrose Hepática Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Gastroenterology Ano de publicação: 2014 Tipo de documento: Article

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