Forazolineâ
A: marine-derived polyketide with antifungal inâ
vivo efficacy.
Angew Chem Int Ed Engl
; 53(43): 11583-6, 2014 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-25197007
ABSTRACT
Forazolineâ
A, a novel antifungal polyketide with inâ
vivo efficacy against Candida albicans, was discovered using LCMS-based metabolomics to investigate marine-invertebrate-associated bacteria. Forazolineâ
A had a highly unusual and unprecedented skeleton. Acquisition of (13)C-(13)C gCOSY and (13)C-(15)N HMQCâ
NMR data provided the direct carbon-carbon and carbon-nitrogen connectivity, respectively. This approach represents the first example of determining direct (13)C-(15)N connectivity for a natural product. Using yeast chemical genomics, we propose that forazolineâ
A operated through a new mechanism of action with a phenotypic outcome of disrupting membrane integrity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Policetídeos
/
Antifúngicos
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2014
Tipo de documento:
Article