Requirement for MHC class II positive accessory cells in an antigen specific bovine T cell response.
Res Vet Sci
; 46(2): 196-201, 1989 Mar.
Article
em En
| MEDLINE
| ID: mdl-2523083
ABSTRACT
Purified populations of bovine antigen presenting cells (APCs) and T cells have been isolated from peripheral blood and characterised using various monoclonal antibodies (mAbs) for cell surface markers. Bovine APCs were found in an adherent cell fraction and were non-specific esterase positive, phagocytic and expressed bovine major histocompatibility complex (MHC) class II determinants, all of which are typical macrophage characteristics. T cells were rigorously depleted of accessory cell function before being used in an antigen presenting cell assay. The generation of T helper cells in response to the soluble antigen, ovalbumin, was entirely dependent upon a critical number of APCs. Further the proliferative response was inhibited by several mAbs to bovine MHC class II molecules. Thus the interaction between bovine APCs and helper/inducer T lymphocytes (TH/I) appears to be similar to that in other species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Antígenos de Histocompatibilidade Classe II
/
Linfócitos T Auxiliares-Indutores
/
Células Apresentadoras de Antígenos
Limite:
Animals
Idioma:
En
Revista:
Res Vet Sci
Ano de publicação:
1989
Tipo de documento:
Article