Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.

Young, D; Fong, D M; Lawlor, P A; Wu, A; Mouravlev, A; McRae, M; Glass, M; Dragunow, M; During, M J

Young, D; Fong, D M; Lawlor, P A; Wu, A; Mouravlev, A; McRae, M; Glass, M; Dragunow, M; During, M J.

Afiliação

Young D; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand [3] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Fong DM; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Lawlor PA; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Wu A; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Mouravlev A; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
McRae M; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Glass M; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Dragunow M; 1] Departments of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand.
During MJ; 1] Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand [2] Centre for Brain Research, University of Auckland, Auckland, New Zealand [3] Department of Molecular Virology, Immunology and Medical Genetics, Neuroscience and Neurological Surgery, Ohio State Unive

Gene Ther ; 21(12): 1029-40, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25231174

Assuntos

Adenosina Quinase/genética; Epilepsia do Lobo Temporal/terapia; Transportador 2 de Aminoácido Excitatório/genética; Marcação de Genes; Terapia Genética/métodos; Glutamato-Amônia Ligase/genética; Adenosina Quinase/metabolismo; Animais; Astrócitos/metabolismo; Transportador 2 de Aminoácido Excitatório/metabolismo; Regulação da Expressão Gênica; Vetores Genéticos; Glutamato-Amônia Ligase/metabolismo; Hipocampo/metabolismo; Ácido Caínico/efeitos adversos; Masculino; Neuroglia/metabolismo; Neurônios/metabolismo; Ratos; Ratos Sprague-Dawley; Convulsões/induzido quimicamente; Transgenes/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Adenosina Quinase / Marcação de Genes / Transportador 2 de Aminoácido Excitatório / Epilepsia do Lobo Temporal / Glutamato-Amônia Ligase Limite: Animals Idioma: En Revista: Gene Ther Assunto da revista: GENETICA MEDICA / TERAPEUTICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Nova Zelândia

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