Non specific pattern of lung function in a respiratory physiology unit: causes and prevalence: results of an observational cross-sectional and longitudinal study.
BMC Pulm Med
; 14: 148, 2014 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-25233902
ABSTRACT
BACKGROUND:
ATS/ERS Task Force has highlighted that special attention must be paid when FEV1 and FVC are concomitantly decreased (<5th percentile) and the FEV1/FVC ratio is normal (>5th percentile) because a possible cause of this non specific pattern (NSP) is collapse of small airways with normal TLC measured by body plethysmography (>5th percentile). Our objectives were to determine the main lung diseases associated with this pattern recorded prospectively in a lung function testing (LFT) unit, the prevalence of this pattern in our LFT and among the diseases identified, and its development.METHODS:
Observational study of routinely collected data selected from our Clinical Database Warehouse.RESULTS:
The prevalence of NSP was 841/12 775 tests (6.6%, 95% CI 6.2 to 7.0%). NSP was mainly associated with seven lung diseases asthma (prevalence of NSP among asthmatics 12.6%), COPD/emphysema (prevalence 8.6%), bronchiectasis (12.8%), sarcoidosis (10.7%), interstitial pneumonia (4.0%), pulmonary hypertension (8.9%) and bilateral lung transplantation for cystic fibrosis (36.0%). LFT measurements were described in 185 patients with NSP and indisputable nonoverlapping causes. A moderate defect (FEV1 66 ± 9% predicted) with mild lung hyperinflation (FRC 111 ± 27%, RV 131 ± 33% predicted suggesting distal airway obstruction) was evidenced whatever the underlying cause. A long term stability of NSP was evidenced in 130/185 patients (70% 95% CI 64 to 77%).CONCLUSIONS:
NSP is observed in asthma, COPD/emphysema, bronchiectasis, sarcoidosis, pulmonary hypertension, interstitial pneumonia and after bilateral lung transplantation and remains stable in the majority of patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Capacidade Vital
/
Volume Expiratório Forçado
/
Pneumopatias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMC Pulm Med
Ano de publicação:
2014
Tipo de documento:
Article