Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K.
Mol Cancer Ther
; 13(12): 2930-40, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25236891
ABSTRACT
Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Extratos Vegetais
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Ribonucleoproteínas Nucleares Heterogêneas Grupo K
/
Vitanolídeos
/
Neoplasias
/
Neovascularização Patológica
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Cancer Ther
Assunto da revista:
ANTINEOPLASICOS
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Japão