Efficient intracellular delivery and multiple-target gene silencing triggered by tripodal RNA based nanoparticles: a promising approach in liver-specific RNAi delivery.

Sajeesh, S; Lee, Tae Yeon; Kim, Joon Ki; Son, Da Seul; Hong, Sun Woo; Kim, Soohyun; Yun, Wan Soo; Kim, Soyoun; Chang, Chanil; Li, Chiang; Lee, Dong-ki

Sajeesh, S; Lee, Tae Yeon; Kim, Joon Ki; Son, Da Seul; Hong, Sun Woo; Kim, Soohyun; Yun, Wan Soo; Kim, Soyoun; Chang, Chanil; Li, Chiang; Lee, Dong-ki.

Afiliação

Sajeesh S; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Lee TY; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Kim JK; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Son DS; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Hong SW; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Kim S; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Yun WS; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Kim S; Department of Medical Biotechnology, Dongguk University, Seoul 100-715, Korea.
Chang C; BMT Inc., Seoul, 153-777, Korea.
Li C; Skip Ackerman Center for Molecular Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Lee DK; Global Research Laboratory for RNAi Medicine, Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea. Electronic address: dklee@skku.edu.

J Control Release ; 196: 28-36, 2014 Dec 28.

Article em En | MEDLINE | ID: mdl-25251899

Assuntos

Inativação Gênica; Fígado/efeitos dos fármacos; Interferência de RNA; RNA Interferente Pequeno/administração & dosagem; RNA Interferente Pequeno/farmacologia; Adjuvantes Imunológicos/farmacologia; Animais; Citocinas/metabolismo; Sistemas de Liberação de Medicamentos; Técnicas de Silenciamento de Genes; Células HeLa; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Nanopartículas; Tamanho da Partícula; Polietilenoimina/química; RNA Interferente Pequeno/metabolismo; Distribuição Tecidual

Palavras-chave

Liver targeting; Nanoparticles; Polyethyleneimine; RNA interference; Tripodal-interfering RNA (tiRNA)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inativação Gênica / RNA Interferente Pequeno / Interferência de RNA / Fígado Limite: Animals / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article

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