Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial.
Acta Paediatr
; 104(4): 396-404, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25283480
ABSTRACT
AIM:
To determine whether vitamin D supplementation reduces primary care visits for acute respiratory infection (ARI).METHODS:
A randomised, double-blind, placebo-controlled trial was conducted in New Zealand and powered to determine the vitamin D dose needed to achieve normal vitamin D status during infancy. Healthy pregnant women, from 27 weeks' gestation to birth, and their infants, from birth to age 6 months, were assigned to placebo or one of the two dosages of daily oral vitamin D3 . Woman/infant pairs were randomised to placebo/placebo, 1000 IU/400 IU or 2000 IU/800 IU. For this ad hoc analysis, the primary care records of enrolled children were audited to age 18 months.RESULTS:
Two hundred and sixty pregnant women were randomised to placebo (n = 87), lower-dose (n = 87) or higher-dose (n = 86) vitamin D3 . In comparison with the placebo group (99%), the proportion of children making any ARI visits was smaller in the higher-dose (87%, p = 0.004), but not the lower-dose vitamin D3 group (95%, p = 0.17). The median number of ARI visits/child was less in the higher-dose vitamin D3 group from age 6-18 months (placebo 4, lower dose 3, higher dose 2.5; p = 0.048 for higher-dose vitamin D3 vs. placebo).CONCLUSION:
Vitamin D3 supplementation during pregnancy and infancy reduces primary care visits for ARI during early childhood.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atenção Primária à Saúde
/
Infecções Respiratórias
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Vitamina D
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Vitaminas
/
Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Nova Zelândia