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Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones.
Hirsch, Danielle R; Cox, Georgina; D'Erasmo, Michael P; Shakya, Tushar; Meck, Christine; Mohd, Noushad; Wright, Gerard D; Murelli, Ryan P.
Afiliação
  • Hirsch DR; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Cox G; M. G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8N 4K1, Canada.
  • D'Erasmo MP; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Shakya T; M. G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8N 4K1, Canada.
  • Meck C; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
  • Mohd N; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States.
  • Wright GD; M. G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8N 4K1, Canada.
  • Murelli RP; Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, United States; Department of Chemistry, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States. Electronic address: rpmurelli@brookl
Bioorg Med Chem Lett ; 24(21): 4943-7, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25283553
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tropolona / Gentamicinas / Farmacorresistência Bacteriana / Escherichia coli / Antibacterianos / Nucleotidiltransferases Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tropolona / Gentamicinas / Farmacorresistência Bacteriana / Escherichia coli / Antibacterianos / Nucleotidiltransferases Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos