A 6-hydroxydopamine-induced selective parkinsonian rat model.
Brain Res
; 494(2): 285-93, 1989 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-2528389
ABSTRACT
Previous parkinsonian rat models have generally been characterized by unilateral destruction of both the nigrostriatal pathway and the mesolimbic pathway using the neurotoxin 6-hydroxydopamine (6-OHDA). We created a hemiparkinsonian model in which there is 6-OHDA-induced destruction of the dopaminergic nigrostriatal pathway but sparing of the dopaminergic mesolimbic pathway. This resulted in reproducible, quantifiable rotational behavior in response to either amphetamine or apomorphine and a near total depletion of dopamine in the striatum ipsilateral to the lesion with a dorsolateral distribution of supersensitive dopaminergic D2 receptors. This model parallels the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced hemiparkinsonian model in primates and more closely approximates the extent of neurodegeneration seen in human idiopathic Parkinson's disease than previous parkinsonian rat models. It may therefore prove a convenient model for studying the recently reported phenomenon of sprouting from host dopaminergic neurons following tissue implantation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson Secundária
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Comportamento Estereotipado
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Receptores Dopaminérgicos
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Modelos Animais de Doenças
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Hidroxidopaminas
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Lateralidade Funcional
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Sistema Límbico
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1989
Tipo de documento:
Article