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Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.
Shen, Lijiang; Frazer-Abel, Ashley; Reynolds, Paul R; Giclas, Patricia C; Chappell, Alfred; Pangburn, Michael K; Younis, Husam; Henry, Scott P.
Afiliação
  • Shen L; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.) lshen@isisph.com.
  • Frazer-Abel A; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Reynolds PR; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Giclas PC; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Chappell A; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Pangburn MK; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Younis H; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
  • Henry SP; Isis Pharmaceuticals, Inc., Carlsbad, California (L.S., A.C., H.Y., S.P.H.); National Jewish Health, Denver, Colorado (A.F.-A., P.R.R., P.C.G.); and University of Texas Health Science Center, Tyler, Texas (M.K.P.).
J Pharmacol Exp Ther ; 351(3): 709-17, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25301170
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligorribonucleotídeos / Oligonucleotídeos Antissenso / Fator H do Complemento / Ativação do Complemento / Compreensão Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligorribonucleotídeos / Oligonucleotídeos Antissenso / Fator H do Complemento / Ativação do Complemento / Compreensão Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2014 Tipo de documento: Article