Highly enantioselective one-pot synthesis of chiral ß-hydroxy sulfones via asymmetric transfer hydrogenation in an aqueous medium.
Org Lett
; 16(21): 5764-7, 2014 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-25341700
ABSTRACT
A mild transformation in an aqueous medium for the one-pot synthesis of optically active ß-hydroxy sulfones is described. The intermediates of ß-keto sulfones obtained via a nucleophilic substitution reaction of α-bromoketones and sodium sulfinates in H2O/MeOH (13, v/v) at 50 °C were reduced through Ru-catalyzed asymmetric transfer hydrogenation in one-pot using HCOONa as a hydrogen source providing a variety of chiral ß-hydroxy sulfones with high yields and excellent enantioselectivities.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2014
Tipo de documento:
Article