Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.

Wang, Shan-Shan; Gu, Yi-Feng; Wolff, Nicholas; Stefanius, Karoliina; Christie, Alana; Dey, Anwesha; Hammer, Robert E; Xie, Xian-Jin; Rakheja, Dinesh; Pedrosa, Ivan; Carroll, Thomas; McKay, Renée M; Kapur, Payal; Brugarolas, James

Wang, Shan-Shan; Gu, Yi-Feng; Wolff, Nicholas; Stefanius, Karoliina; Christie, Alana; Dey, Anwesha; Hammer, Robert E; Xie, Xian-Jin; Rakheja, Dinesh; Pedrosa, Ivan; Carroll, Thomas; McKay, Renée M; Kapur, Payal; Brugarolas, James.

Afiliação

Wang SS; Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Gu YF; Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Wolff N; Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Stefanius K; Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Christie A; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Dey A; Department of Molecular Oncology, Genentech, South San Francisco, CA 94080.
Hammer RE; Biochemistry.
Xie XJ; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Rakheja D; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Pathology, Pediatrics.
Pedrosa I; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Radiology, and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; and.
Carroll T; Internal Medicine (Nephrology) and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390;
McKay RM; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Kapur P; Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Pathology, payal.kapur@utsouthwestern.edu james.brugarolas@utsouthwestern.edu.
Brugarolas J; Hematology-Oncology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Departments of Developmental Biology, Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; payal

Proc Natl Acad Sci U S A ; 111(46): 16538-43, 2014 Nov 18.

Article em En | MEDLINE | ID: mdl-25359211

Assuntos

Carcinoma de Células Renais/genética; Modelos Animais de Doenças; Genes Supressores de Tumor; Falência Renal Crônica/genética; Neoplasias Renais/genética; Proteínas Supressoras de Tumor/fisiologia; Ubiquitina Tiolesterase/fisiologia; Proteína Supressora de Tumor Von Hippel-Lindau/fisiologia; Idade de Início; Alelos; Animais; Linhagem da Célula; Mapeamento Cromossômico; Feminino; Genes Reporter; Genes Sintéticos; Predisposição Genética para Doença; Humanos; Doenças Renais Císticas/genética; Doenças Renais Císticas/patologia; Falência Renal Crônica/sangue; Falência Renal Crônica/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Modelos Genéticos; Células-Tronco Multipotentes/metabolismo; Células-Tronco Multipotentes/patologia; Mutação; Fenótipo; Lesões Pré-Cancerosas/genética; Lesões Pré-Cancerosas/patologia; Especificidade da Espécie; Proteínas Supressoras de Tumor/antagonistas & inibidores; Proteínas Supressoras de Tumor/genética; Ubiquitina Tiolesterase/antagonistas & inibidores; Ubiquitina Tiolesterase/genética; Proteína Supressora de Tumor Von Hippel-Lindau/antagonistas & inibidores; Proteína Supressora de Tumor Von Hippel-Lindau/genética

Palavras-chave

BAP1; Six2-Cre; VHL; kidney cancer; kidney stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Genes Supressores de Tumor / Proteínas Supressoras de Tumor / Ubiquitina Tiolesterase / Modelos Animais de Doenças / Proteína Supressora de Tumor Von Hippel-Lindau / Falência Renal Crônica / Neoplasias Renais Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article

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