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Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
Rozot, Virginie; Patrizia, Amelio; Vigano, Selena; Mazza-Stalder, Jesica; Idrizi, Elita; Day, Cheryl L; Perreau, Matthieu; Lazor-Blanchet, Catherine; Ohmiti, Khalid; Goletti, Delia; Bart, Pierre-Alexandre; Hanekom, Willem; Scriba, Thomas J; Nicod, Laurent; Pantaleo, Giuseppe; Harari, Alexandre.
Afiliação
  • Rozot V; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
  • Patrizia A; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Vigano S; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Mazza-Stalder J; Division of Pneumology.
  • Idrizi E; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Day CL; South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
  • Perreau M; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Lazor-Blanchet C; Occupational Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.
  • Ohmiti K; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Goletti D; National Institute for Infectious Diseases, Rome, Italy.
  • Bart PA; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.
  • Hanekom W; South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
  • Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
  • Nicod L; Division of Pneumology.
  • Pantaleo G; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland Swiss Vaccine Research Institute, Lausanne, Switzerland.
  • Harari A; Division of Immunology and Allergy, Lausanne University Hospital, Switzerland Swiss Vaccine Research Institute, Lausanne, Switzerland.
Clin Infect Dis ; 60(3): 432-7, 2015 Feb 01.
Article em En | MEDLINE | ID: mdl-25362202
ABSTRACT
Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Mycobacterium tuberculosis / Antígenos de Bactérias Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Mycobacterium tuberculosis / Antígenos de Bactérias Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: África do Sul