Neuroglobin - recent developments.
Biomol Concepts
; 5(3): 195-208, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-25372753
ABSTRACT
Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb's protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb's function in neurite outgrowth.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Globinas
/
Astrócitos
/
Neuritos
/
Neoplasias
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomol Concepts
Ano de publicação:
2014
Tipo de documento:
Article