Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin.

Sahu, Ravi P; Rezania, Samin; Ocana, Jesus A; DaSilva-Arnold, Sonia C; Bradish, Joshua R; Richey, Justin D; Warren, Simon J; Rashid, Badri; Travers, Jeffrey B; Konger, Raymond L

Sahu, Ravi P; Rezania, Samin; Ocana, Jesus A; DaSilva-Arnold, Sonia C; Bradish, Joshua R; Richey, Justin D; Warren, Simon J; Rashid, Badri; Travers, Jeffrey B; Konger, Raymond L.

Afiliação

Sahu RP; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Rezania S; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Ocana JA; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
DaSilva-Arnold SC; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Bradish JR; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Richey JD; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Warren SJ; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Rashid B; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.
Travers JB; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, 46202, United States of America.
Konger RL; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America.

PLoS One ; 9(11): e111608, 2014.

Article em En | MEDLINE | ID: mdl-25375862

Assuntos

Anti-Inflamatórios/administração & dosagem; Antineoplásicos/administração & dosagem; Inflamação/induzido quimicamente; Inflamação/tratamento farmacológico; Glicoproteínas da Membrana de Plaquetas/agonistas; Receptores Acoplados a Proteínas G/agonistas; Neoplasias Cutâneas/tratamento farmacológico; 9,10-Dimetil-1,2-benzantraceno; Administração Tópica; Animais; Modelos Animais de Doenças; Orelha; Epiderme/efeitos dos fármacos; Epiderme/patologia; Camundongos; Camundongos Endogâmicos C57BL; Ésteres de Forbol/efeitos adversos; Glicoproteínas da Membrana de Plaquetas/genética; Proteínas Proto-Oncogênicas c-kit/genética; Proteínas Proto-Oncogênicas c-kit/metabolismo; Receptores Acoplados a Proteínas G/genética; Neoplasias Cutâneas/induzido quimicamente

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Glicoproteínas da Membrana de Plaquetas / Receptores Acoplados a Proteínas G / Inflamação / Anti-Inflamatórios / Antineoplásicos Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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