Pathogenesis and molecular biology of a transmissible tumor in the Tasmanian devil.
Annu Rev Anim Biosci
; 2: 165-87, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-25384139
ABSTRACT
The emergence of a fatal transmissible cancer known as devil facial tumor disease (DFTD) is threatening the iconic Tasmanian devil with extinction in the wild within the next few decades. Since the first report of the disease in 1996, DFTD has spread to over 85% of the devils' distribution and dramatically reduced devil numbers. Research into DFTD has focused on gaining a deeper understanding of the disease on multiple levels, including an accurate assessment of the tissue origin of the tumor, elucidation of how the tumor evades immune detection, and determination of how the tumor is transmitted between individuals and how it is evolving as it spreads through the population. Knowledge gained from these studies has important implications for DFTD management and devil conservation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Faciais
/
Evolução Clonal
/
Marsupiais
/
Neoplasias
Tipo de estudo:
Etiology_studies
Limite:
Animals
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Annu Rev Anim Biosci
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Austrália