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In vitro activity of clinically implemented ß-lactams against Aerococcus urinae: presence of non-susceptible isolates in Switzerland.
Lupo, Agnese; Guilarte, Yuvia N; Droz, Sara; Hirzel, Cèdric; Furrer, Hansjakob; Endimiani, Andrea.
Afiliação
  • Lupo A; Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Friedbühlstrasse 51, CH-3010 Bern, Switzerland.
New Microbiol ; 37(4): 563-6, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25387295
ABSTRACT
We analyzed the in vitro susceptibility to several ?-lactams and vancomycin of 80 Aerococcus urinae isolates collected during 2011-2012 in Switzerland. MICs were determined by Etest (bioMérieux) on Müller-Hinton agar with 5% sheep blood and interpreted according to the CLSI and EUCAST criteria set for viridans streptococci. MIC50/90 for penicillin, amoxicillin, ceftriaxone and vancomycin were 0.016/0.064 mg/l, 0.032/0.064 mg/l, 0.125/0.5 mg/l and 0.38/0.5 mg/l, respectively. Three (3.8%) isolates were resistant to ceftriaxone regardless of the criteria used (MICs ?2 mg/l); one of them was also non-susceptible to penicillin (MIC of 0.25 mg/l) according to CLSI. ß-lactam resistance in A. urinae is a concern and suggests that more studies are needed to determine the molecular mechanisms of such resistance.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Positivas / Beta-Lactamas / Aerococcus / Antibacterianos Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: New Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Positivas / Beta-Lactamas / Aerococcus / Antibacterianos Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: New Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Suíça