[Non-ciliary functions of cilia proteins]. / De nouvelles fonctions extraciliaires pour les protéines ciliaires - quelles conséquences sur l'apparition de ciliopathies ?
Med Sci (Paris)
; 30(11): 1040-6, 2014 Nov.
Article
em Fr
| MEDLINE
| ID: mdl-25388587
ABSTRACT
Cilia proteins have long been characterized for their role in cilia formation and function, and their implications in ciliopathies. However, several cellular defects induced by cilia proteins deregulation suggest that they could have non-ciliary roles. Indeed, several non-ciliary functions have been recently characterized for cilia proteins including roles in intra-cellular and in vesicular transport, in spindle orientation or in the maintenance of genomic stability. These observations thus raise the crucial question of the contribution of non-ciliary functions of cilia proteins to the pathological manifestations associated with ciliopathies such as polycystic kidney disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Proteínas de Ciclo Celular
/
Proteínas Motores Moleculares
/
Transporte Proteico
/
Instabilidade Genômica
/
Proteínas dos Microtúbulos
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França