Neural-competent cells of adult human dermis belong to the Schwann lineage.
Stem Cell Reports
; 3(5): 774-88, 2014 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-25418723
ABSTRACT
Resident neural precursor cells (NPCs) have been reported for a number of adult tissues. Understanding their physiological function or, alternatively, their activation after tissue damage or in vitro manipulation remains an unsolved issue. Here, we investigated the source of human dermal NPCs in adult tissue. By following an unbiased, comprehensive approach employing cell-surface marker screening, cell separation, transcriptomic characterization, and in vivo fate analyses, we found that p75NTR(+) precursors of human foreskin can be ascribed to the Schwann (CD56(+)) and perivascular (CD56(-)) cell lineages. Moreover, neural differentiation potential was restricted to the p75NTR(+)CD56(+) Schwann cells and mediated by SOX2 expression levels. Double-positive NPCs were similarly obtained from human cardiospheres, indicating that this phenomenon might be widespread.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Schwann
/
Linhagem da Célula
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Derme
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Células-Tronco Neurais
Limite:
Adolescent
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Adult
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Aged
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Animals
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Child
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Child, preschool
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Revista:
Stem Cell Reports
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha