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Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.
Burschowsky, Daniel; van Eerde, André; Ökvist, Mats; Kienhöfer, Alexander; Kast, Peter; Hilvert, Donald; Krengel, Ute.
Afiliação
  • Burschowsky D; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway; and.
  • van Eerde A; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway; and.
  • Ökvist M; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway; and.
  • Kienhöfer A; Laboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.
  • Kast P; Laboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland ute.krengel@kjemi.uio.no kast@org.chem.ethz.ch hilvert@org.chem.ethz.ch.
  • Hilvert D; Laboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland ute.krengel@kjemi.uio.no kast@org.chem.ethz.ch hilvert@org.chem.ethz.ch.
  • Krengel U; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway; and ute.krengel@kjemi.uio.no kast@org.chem.ethz.ch hilvert@org.chem.ethz.ch.
Proc Natl Acad Sci U S A ; 111(49): 17516-21, 2014 Dec 09.
Article em En | MEDLINE | ID: mdl-25422475

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bacillus subtilis / Corismato Mutase Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bacillus subtilis / Corismato Mutase Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article